If you are keeping it a long time it's difficult to beat a Lexus/Toyota. I have a 2010 Sequoia and a 2010 Tundra with a supercharger so I'm definitely a fan. The Sequoia is great for highway cruising and is really comfortable with independent front and rear suspension. And of course the Tundra can move a lot of cargo relatively. And Land Cruisers are a bit smaller than either of those, but have the same 5.7l. they're just known for long term durability and are a bit better off-road.
It all really depends on what you want.
There are a lot of good coyote Mustangs out there as well as Cameros if you want affordable power and handling (and a manual). A newer Mach 1 mustang has a good amount of options for performance, as well as the preferable tremac manual transmission, but those are probably up there in price.
I've always wanted to try a Lexus RCF, which look great for cruising in comfort.